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International Journal of Radiation Research، جلد ۱۲، شماره ۲، صفحات ۸۱-۹۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Human 3-D tissue models in radiation biology: current status and future perspectives
چکیده انگلیسی مقاله In this review, we discuss the use of a variety of 3-D models (particularly 3-D skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-D culturing conditions (monolayers). We review the characteristics of existing 3-D models and aim to point out the substantial advantages 3-D cultures provide for modern radiobiology. In particular, they may facilitate the shift from the classical DNA damage and repair studies mainly carried out in monolayer cultures to the investigation of more generalized responses through pathway analysis and a system biology approach. 3-D models are expected to be very informative for investigations on radiotherapy responses in addressing the low dose risk. However, the 3-D model systems are not as easy to propagate and standardize as monolayer cultures. Therefore, we discuss the problems and limitations of 3-D models and propose ways to overcome some of the problems.
کلیدواژه‌های انگلیسی مقاله 3-D tissue models, radiation biology
نویسندگان مقاله a acheva | a. acheva
stuk - radiation and nuclear safety authority, laippatie 4, 00880 helsinki, finland


a aerts | a. aerts
sck•cen - belgian nuclear research centre, radiobiology unit, boeretang 200, b-2400 mol, belgium


ch rombouts | ch. rombouts
sck•cen - belgian nuclear research centre, radiobiology unit, boeretang 200, b-2400 mol, belgium


s baatout | s. baatout
sck•cen - belgian nuclear research centre, radiobiology unit, boeretang 200, b-2400 mol, belgium


s salomaa | s. salomaa
stuk - radiation and nuclear safety authority, laippatie 4, 00880 helsinki, finland


k manda | k. manda
department of radiotherapy and radiation oncology, university hospital rostock, südring 75, d-18059 rostock, germany


g hildebrandt | g. hildebrandt
department of radiotherapy and radiation oncology, university hospital rostock, südring 75, d-18059 rostock, germany


m kämäräinen | m kämäräinen
stuk - radiation and nuclear safety authority, laippatie 4, 00880 helsinki, finland
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-494&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مرور و بررسی کلی
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