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International Journal of Radiation Research، جلد ۱۲، شماره ۲، صفحات ۱۲۳-۱۲۸
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عنوان انگلیسی Alterations of PSA, CA15.3, CA125, Cyfra21-1, CEA, CA19.9, AFP and Tag72 tumor markers in human blood serum due to long term exposure to high levels of natural background radiation in Ramsar, Iran
چکیده انگلیسی مقاله Background: Ramsar (Mazandran province) is known for its extremely high levels of natural background radiation. Although no excess cancer rate is reported in these areas by epidemiological studies, the study of tumor markers in the inhabitants of these areas may shed some light on the impact of high levels of background radiation on cancer induction. Materials and Methods: The level of background gamma radiation as well as indoor radon was determined using RDS-110 and CR-39 dosimeters. Thirty five individuals from a high background radiation area (HBRA) and 53 individuals from a normal background radiation area (NBRA) were randomly selected to participate in the study. Commercial ELISA kits (sandwich type ELISA tests) were used to measure the serum levels of PSA, CA15.3, CA125, Cyfra21-1, CEA, CA19.9, AFP and Tag72 tumor markers. Results: Among the eight biomarkers investigated, the means of PSA, CA15.3, CA125, CA19.9 and AFP concentrations between the HBRAs and NBRAs were not significantly different. However, Cyfra21, CEA and Tag72 in HBRA group revealed statistically significant increases compared to those of NBRA group (P< 0.05). Furthermore, a statistically significant correlation between the external gamma dose as well as indoor radon level and the concentration of CEA (P< 0.001), Cyfra-21(P< 0.001) and TAG 72 (P< 0.001 and 0.01 respectively) biomarkers were observed. Conclusion: Chronic exposure to high background radiation induces significant alterations in Cyfra21, CEA and Tag72 levels. We believe that studies with other relevant tumor markers might overcome the limitations of epidemiological studies on cancer incidence in high background radiation areas.
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نویسندگان مقاله s تایب | s. taeb
the center for research in radiation sciences crrs , school of paramedical sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سید محمد جواد مرتضوی | s m j mortazavi
the center for research in radiation sciences crrs , school of paramedical sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

a قادری | a. ghaderi
cancer institute, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

h مزدارانی | h. mozdarani
department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

ce de almeida | ce de almeida
laboratório de ciências radiológicas lcr da universidade do estado do rj uerj , rio de janeiro, brazil


محمدرضا کاردان | m r kardan
national radiation protection department nrpd , tehran, iran


سیدعلیرضا مرتضوی | s a r mortazavi
student research committee, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

a سلیمانی | a. soleimani
department of epidemiology, school of health, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

i نیکوکار | i. nikokar
laboratory of immunology and microbiology of infectious diseases, paramedicine faculty, guilan university of medical sciences, guilan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

m حقانی | m. haghani
the center for research in radiation sciences crrs , school of paramedical sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-497&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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