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International Journal of Radiation Research، جلد ۱۰، شماره ۳، صفحات ۱۸۳-۱۸۶
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عنوان انگلیسی Megavoltage dose enhancement of gold nanoparticles for different geometric set-ups: Measurements and Monte Carlo simulation
چکیده انگلیسی مقاله Background: Gold nanoparticles (GNPs) have been shown as a good radiosensitizer. In combination with radiotherapy, several studies with orthovoltage X-rays have shown considerable dose enhancement effects. This paper reports the dose enhancement factor (DEF) due to GNPs in 18 megavoltage (MV) beams. Materials and Methods: Different geometrical 50-nm GNPs configurations at a concentration of 5 mg/ml were used by both experimental and Monte Carlo (MC) simulation in a deep-seated tumor-like insertion within a phantom. Using MCNP repeated structure capability a large number of gold nanospheres with a semi-random distribution were applied to simulate this phantom based study. Thermoluminescence dosimetries were used to verify the process of irradiation and MC simulation. Results: Under geometries with different probable combinations of water and GNPs distribution in the tumor, the percentage depth dose and DEF were calculated. Incorporation of GNPs into the radiation field in our set-ups showed a 12% DEF. Conclusion: We show that the method of nanoparticles, distribution, and orientation can effectively change the DEF value. Iran. J. Radiat. Res., 2012 10(3‐4): 183‐186
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نویسندگان مقاله سید حسین موسوی انیجدان | s h mousavie anijdan
department of medical physics and engineering, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a شیرازی | a. shirazi
department of medical physics and engineering, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سیدرضا مهدوی | s r mahdavi
department of medical physics and engineering, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a عزتی | a. ezzati
department of energy engineering, sharif university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی شریف (Sharif university of technology)

b مفید | b. mofid
department of radiation oncology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

s خویی | s. khoei
department of medical physics and engineering, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدعلی زرین فرد | m a zarrinfard
department of medical nanotechnology, faculty of advanced medical sciences, tehran, iran
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-442&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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