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Iranian Biomedical Journal، جلد ۲۳، شماره ۶، صفحات ۳۸۸-۳۹۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antitumor Effects of HPV DNA Vaccine Adjuvanted with Beclin-1 as an Autophagy Inducer in a Mice Model
چکیده انگلیسی مقاله Background: There is a growing interest in development of an effective adjuvant system for improving DNA vaccines. Recent findings have confirmed an important role for autophagy in both innate and adaptive immunity. The current study was undertaken to determine the efficacy of autophagy induction with Beclin-1, as a novel adjuvant system, in mice immunized with human papilloma virus (HPV) DNA vaccine. Methods: To determine whether autophagy induction with Beclin-1 enhances the efficacy of HPV DNA vaccine, female C57BL/6 mice were challenged with TC-1 tumor cells and were immunized three times at one-week intervals. Two weeks after the final immunization, the mice were sacrificed, and the antitumor effects were assessed by measurement of lymphocyte proliferation, cytotoxicity, cytokine production, and tumor regression. Results: Beclin-1 in combination with HPV-16 DNA vaccine encoding the E7 antigen induced a higher level of lymphocyte proliferation and cytotoxicity than the DNA vaccine alone. The novel combination increased the production of IFN-γ and highly inhibited tumor progression in comparison with DNA vaccine alone. Conclusion: Administration of Beclin-1, as an autophagy inducer, with HPV DNA vaccine produces antitumor effects, providing an effective adjuvant for the induction of a strong antitumor immune response. 
کلیدواژه‌های انگلیسی مقاله Adjuvants, Autophagy, Beclin-1
نویسندگان مقاله | Hamed Naziri
Department of Immunology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran


| Alireza Tahamtan
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran


| Maryam Dadmanesh
Department of Infectious Diseases, School of Medicine, Aja University of Medical Sciences, Tehran, Iran


| Mohammad Barati
Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran


| Khodayar Ghorban
Department of Immunology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-787&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-1938737.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Immunology & Vaccines
نوع مقاله منتشر شده مقاله کامل
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