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Iranian Biomedical Journal، جلد ۲۳، شماره ۶، صفحات ۴۲۳-۴۲۸
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian Patients
چکیده انگلیسی مقاله Background: Hypercoagulability and hypofibrinolysis are among the symptoms exhibited by diabetic patients. Our study aimed to address the polymorphic nature of Alu DNA fragment in the human tissue plasminogen activator gene within diabetes mellitus (DM) Jordanian patients. Methods: Genomic DNA was isolated from 76 DM patients and 60 non-diabetic Jordanian individuals, and the Alu fragment was amplified using PCR. Results: The results showed that 80% of the non-diabetic Jordanian subjects were homozygotes for the deletion of the Alu fragment (Alu-/-), 16.7% were homozygotes for its insertion (Alu+/+), and 3.3% were heterozygotes (Alu+/-). Besides, 36.8% of the diabetic patients exhibited the Alu-/- or Alu+/- genotype, and 26.3% were Alu+/+. The Alu-/- genotype occurred less frequently in the diabetic individuals. Conclusion: The high frequency of the Alu-/- genotype constitutes a protective deletion with respect to DM within the normal subjects. 
کلیدواژه‌های انگلیسی مقاله Alu, Diabetes mellitus, Polymorphism
نویسندگان مقاله | Salem R. Yasin
1Department of Biology and Biotechnology, Faculty of Science, the Hashemite University, Zarqa, Jordan


| Hussam H. AlHawari
Department of Internal Medicine, Faculty of Medicine, University of Jordan, Amman, Jordan


| Abeer A. Alassaf
Department of Pediatric, Faculty of Medicine, University of Jordan, Amman, Jordan


| Maysa M. Khadra
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Jordan, Amman, Jordan


| Zainab A. Al-Mazaydeh
Department of Biology and Biotechnology, Faculty of Science, the Hashemite University, Zarqa, Jordan


| Ala'a F. Al-Emerieen
Department of Service Courses, Faculty of Science, Zarqa Private University, Zarqa, Jordan


| Lubna H. Tahtamouni
Department of Biology and Biotechnology, Faculty of Science, the Hashemite University, Zarqa, Jordan
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-779&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-1938741.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Genetics & Genomics
نوع مقاله منتشر شده مقاله کوتاه
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