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International Journal of Radiation Research، جلد ۱۰، شماره ۱، صفحات ۵۹-۶۲
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عنوان انگلیسی Preparation and quality control of 153Sm-[tris(1,10 -phenanthroline) samarium (III)] complex
چکیده انگلیسی مقاله Background: The 153Sm-[tris(1,10-phenanthroline) Samarium(III)]complex (153Sm-PL3) was prepared in view of development of targeting therapeutic compounds for malignancies, and interesting in-vitro anti-tumor activities of lanthanide phenanthroline complexes,. Materials and Methods: Sm-153 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of enriched 152Sm2O3 sample, dissolved in acidic media. The labeling was performed in ethanol in 24h, controlled by ITLC (1.0mM DTPA, pH.5, as mobile phase). The partition coefficient for the labeled compound was also determined. Results: A radiochemical yield of more than 95% was obtained. Radiochemical purity of 96% was obtained using ITLC with specific activity of about 27.75 GBq/mg. The radio-labeled complex was stable in aqueous solution at least 24 hours and no significant amount of free 153Sm was released from the complex. The partition coefficient for the labeled compound was determined (log P. 3.4). The complex was stable in final formulation for 66h. The biological evaluation of the compound is under investigation. Conclusion: The radiolabeled compound used in this study was a very inexpensive and useful agent for the use as a therapeutic compound. Iran. J. Radiat. Res., 2012 10(1): 59-62
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نویسندگان مقاله z ناصری | z. naseri
school of chemistry, university college of science, university of tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

a حکیمی | a. hakimi
health physics and dosimetry research laboratory, department of physics, amir kabir university of technology, tehran, iran


s شیروانی آرانی | s shirvani arani
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , tehran, iran


علیرضا جلیلیان | a r jalilian
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , tehran, iran


a بهرامی سامانی | a bahrami samani
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , tehran, iran


m نعمتی خراط | m nemati kharat
school of chemistry, university college of science, university of tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

m قنادی مراغه | m ghannadi maragheh
radiopharmaceutical research and development lab rrdl , nuclear science and technology research institute nstri , tehran, iran
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-421&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مرور و بررسی کلی
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