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International Journal of Radiation Research، جلد ۸، شماره ۲، صفحات ۶۱-۷۴
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عنوان انگلیسی Dosimetry limitations and pre-treatment dose profile correction for sliding window IMRT
چکیده انگلیسی مقاله Background: This work investigated the dosimetry limitations of the random and systematic uncertainties of sliding window (SW) intensity modulated radiation therapy (IMRT). Materials and Methods: A Varian 21EX linear accelerator, Pinnacle3 treatment planning system and radiographic film dosimetry was used. The limitations of the SW were studied using beam modulation ranging from 2 to 100 MU/beam, DR from 100 to 600 MU min-1, LV from 1 to 5 cm s-1 and field size up to 12 × 12 cm2. The random and systematic errors were investigated using clinical and flat beams, as well as beams of high profile modulation including linear, exponential, and sinusoidal profiles. Results: The leading edge and plateau of the SW profiles have a significant deformation for higher DR and for beams of < 10 MUs/beam. It was found that the error is directly proportional to the DR and LV, and inversely proportional to the number of MU/beam. Conclusion: The high DR and LV are limiting factors, producing random profile deformation when SW beams of small number of MU/beam are delivered. A very good agreement was found between the planned and delivered geometrical and clinical dose profiles when beams > 10 MUs irradiated by a DR from 100 to 600 MU min-1 and LV from 1 to 5 cm s-1. After the proposed correction, an average difference < 0.5% for clinical profiles was measured for beams irradiated with DR = 600 MU min-1 and LV= 5 cm s-1. It was concluded that this correction methodology may serve as a pre-treatment Quality Assurance tool for SW IMRT beams. Iran. J. Radiat. Res., 2010 8 (2): 61-74
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نویسندگان مقاله g grigorov | g. grigorov
grand river regional cancer center, grand river hospital, p.o. box 9056, 835 king street west, kitchener, on, canada n2g 1g3


j c l chow | j c l chow
radiation medicine program, princess margaret hospital, 610 university avenue, toronto, on, canada m5g 2m9


n یزدانی | n. yazdani
grand river regional cancer center, grand river hospital, p.o. box 9056, 835 king street west, kitchener, on, canada n2g 1g3
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-353&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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