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International Journal of Radiation Research، جلد ۸، شماره ۱، صفحات ۲۵-۲۹
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عنوان انگلیسی Induction of chromosomal aberrations in human primary fibroblasts and immortalized cancer cells exposed to extremely-low-frequency electromagnetic fields
چکیده انگلیسی مقاله Background: Rapidly increasing possibilities of exposure to environmental extremely low-frequency electromagnetic fields (ELF-EMF) have become a topic of worldwide investigation. Epidemiological and laboratory studies suggest that exposure to ELF-EMF may increase cancer risk therefore assessment of chromosomal damage in various cell lines might be of predictive value for future risk estimation. Materials and Methods: Primary cultures of fibroblasts from human skin biopsy were exposed to continuous extremely low-frequency electromagnetic fields (3, 50 and 60 Hz, sinusoidal, 3h, and 4 mT). Also immortalized cell lines, SW480, MCF-7 and 1321N1 were exposed to continuous ELF-EMF (50 Hz, sinusoidal, 3 h, 4 mT). Metaphase plates were prepared according to standard methods and stained in 5% Giemsa solution. Chromosomal aberrations of both chromosome and chromatid types were scored to evaluate the effects of ELF-EMF on primary or established cell lines. Results: Results indicate that by increasing the frequency of ELF-EMF, chromosomal aberrations were increased up to 7-fold above background levels in primary human fibroblast cells. In addition, continuous exposure to a 50 Hz electromagnetic field led to a significant increase in chromosomal aberrations in SW480, MCF-7 and 1321N1 cell lines compared to sham control. Conclusion: Results obtained indicate that ELF-EMF has the potential for induction of chromosomal aberrations in all cell types. Iran. J. Radiat. Res., 2010 8 (1): 25-29
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نویسندگان مقاله سید سعید سیدی | s s seyyedi
proteomic research center, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

h مزدارانی | h. mozdarani
department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

m رضایی طاویرانی | m rezaei tavirani
faculty of paramedical sciences, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

s حیدری | s. heydari
proteomic research center, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-347&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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