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International Journal of Radiation Research، جلد ۵، شماره ۲، صفحات ۷۹-۸۳
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عنوان انگلیسی [Methyl-14C]-choline incorporation into nude mice bearing tumor xenografts-correlation with [methyl-3H]-thymidine: A pilot study
چکیده انگلیسی مقاله Background: Many in vitro studies suggested that choline incorporation into many types of tumors is related to cell proliferation. Whether in vivo choline incorporation is related also to cell proliferation or not was my question. Therefore, the aim of this pilot study was to investigate the relationship of in vivo [methyl- 14C]-choline incorporation and in vivo [methyl-3H]- thymidine incorporation. Materials and Methods: Four female nude mice were inoculated with MCF-7 breast tumor cells. Tumors were allowed to grow to a diameter of 0.5 cm and a diameter of 1 cm. Radioactivity of 370 kBq [methyl-14C]-choline and [methyl-3H]-thymidine each was injected. After 10 min, tumors were harvested and extracted with organic and aqueous solvents. The total [methyl-3H]-thymidine and [methyl-14C]-choline were determined and correlated using Spearman's rank (rs) coefficient at 0.5 cm (n=4) and 1 cm (n=3) tumors. Results: Spearman's rank (rs) correlation coefficient showed high rs=0.8 (p=0.2 n=4) at 0.5 cm tumor compared to low rs=0.5 (p=0.7 n=3) at 1 cm tumor. Conclusion: In this preliminary pilot study, in vivo [methyl-14C]-choline incorporation may correlate with cell proliferation. More number of investigations is recommended.
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نویسندگان مقاله فاطمه al سعیدی | fatima al saeedi
department of nuclear medicine, faculty of medicine, kuwait university health sciences centre , p.o. box 24923 postal code 13110 safat, kuwait.
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-237&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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