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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۳، صفحات ۲۶۳-۲۷۲
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عنوان انگلیسی Phytochemical analysis and antiproliferative activity of the aerial parts of Scrophularia subaphylla
چکیده انگلیسی مقاله Scrophularia subaphylla ( S. subaphylla ) L., a medicinal plant from the Scrophulariaceae family, has been reported to possess potential profits in the treatment and prophylaxis of different diseases. Some phenolic compounds in this genus have been displayed decent effects on different types of cancer via multiple mechanisms. The current study aimed to bioassay guided isolation of cytotoxic constituents from the aerial parts of S. subaphylla against breast (MCF-7) and colon (HT-29) cancer cell lines as well as normal cells (L929). Different extracts of S. subaphylla were acquired by Soxhlet apparatus and then subjected to brine shrimp lethality test and MTT assay for assessing their cytotoxic characteristics. Cytotoxic extract subjected to further phytochemical fractionation using solid phase extraction, reversed-phase high pressure liquid chromatography (RP-HPLC), and one dimensional nuclear magnetic resonance (1D-NMR) spectroscopy. The biological activity of the isolated pure components, verbascoside and 3 ' O rhamnosyl -4' O para coumaryl 7- hydroxyl salidroside , was assessed using MTT assay against MCF-7 and HT-29 carcinoma cells. Two known phenylpropanoid compounds were isolated from this species. Their structures were elucidated by spectroscopic data (using 1 H-NMR and 13 C-NMR) and compared with the previous literature. Both pure compounds in comparison with control group demonstrated significant antiproliferative activity against cancerous cells ( P < 0.001). In our study, verbascoside and its derivative could inhibit proliferation of cancerous cells without any side effects on normal cells.
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نویسندگان مقاله | Abbas Delazar
3Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Solmaz Asnaashari
4Research Center of Medicinal herbs, Maragheh University of Medical Sciences, Maragheh, I.R. Iran.


| Elhameh Nikkhah
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran. 2Faculty of pharmacy, Tabriz University of Medical Sciences, Tabriz, I.R. Iran. 5Halal Research Center of IRI, FDA, Tehran, I.R. Iran.


| Parina Asgharian


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1902
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955257.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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