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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۳۰-۱۳۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis and cytotoxic evaluation of some derivatives of triazole-quinazolinone hybrids
چکیده انگلیسی مقاله Triazoles and quinazolinones are important heterocyclic structures with diverse biological properties including cytotoxic, antibacterial, antifungal and anticonvulsant activities. Due to valuable cytotoxic effects of both triazole and quinazoline derivatives, in this study a series of quinazolinone-triazole hybrids were synthesized in a multiple-step reaction procedure. 3-Amino-quinazolinone derivatives were treated with chloroacetyl chloride in the presence of dichloromethane/triethylamine to afford 2-chloro -N-(4-oxo-2-quinazolin3 (3H)-yl) acetamide derivatives. The reaction of resultants with 4 - mehyl-4-H-1, 2, 4-triazole-3-thiol in dry acetone and potassium carbonate led to the formation of final products. Synthesized compounds were evaluated for their cytotoxic effects against MCF-7 and Hela cell lines using MTT colorimetric assay. Amongst tested compounds, 6a showed the highest cytotoxic activity against MCF7 cell line at all tested concentrations while compounds 6b and 6c indicated mild cytotoxic effects against Hela cell line at highest tested concentration reducing cell viability about 40%. The IC 50 values of tested compounds revealed that the MCF-7 is more susceptible to the compound 6a .
کلیدواژه‌های انگلیسی مقاله Cytotoxicity,Hybrid,Quinazolinone,Triazole.
نویسندگان مقاله | Farshid Hassanzadeh
1Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Hojjat Sadeghi-aliabadi1
1Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Shadan Nikooei
1Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Elham Jafari
2Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, I. R. Iran.


| Golnaz Vaseghi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1888
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955262.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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