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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۳۸-۱۴۵
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عنوان انگلیسی Effects of ethanolic extract of Ferula gummosa oleo-resin in a rat model of streptozotocin-induced diabetes
چکیده انگلیسی مقاله Previous studies have shown that some plants in the genus of Ferula (Apiaceae) have antidiabetic effects. The present work was aimed to evaluate effects of Ferula gummosa oleo-resin in a rat model of streptozotocin-induced diabetes. Male Wistar rats were randomized into five groups (n = 6): normal control, diabetic control, diabetic rats treated with insulin (3 IU/day), and diabetic rats treated with 100 or 400 mg/kg/day of an ethanolic extract of the oleo-resin. After 4 weeks, blood samples were collected for measuring fasting blood glucose (FBG), lipid profile, aspartate aminotransferase, alanine aminotransferase (ALT), alkaline phosphatase, blood urea nitrogen, and creatinine. In addition, levels of lipid peroxidation, thiol groups, and superoxide dismutase (SOD) activity were evaluated in the liver and kidney. At the end of the fourth week, the level of FBG in rats treated with 100 mg/kg of the extract was lower than that in diabetic control rats (273 ± 39 mg/dL vs 471 ± 32 mg/dL). Administration of insulin and the extract had no significant effects on the serum lipids. Insulin and both doses of the extract significantly reduced the activity of ALT. In addition, the extract inhibited lipid peroxidation in the kidney and restored the elevated level of SOD in the liver and kidneys. Ferula gummosa oleo-resin has the potential to prevent or delay the complications of diabetes by inhibiting the progression of hyperglycemia and attenuating oxidative stress-induced damage in the liver and kidneys.
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نویسندگان مقاله | Mohammad Jalili-Nik
1Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| Mohammad Soukhtanloo
2Student Research Committee, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| Sajad Javanshir
3Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| Amirali Jahani Yazdi
4Department of Basic Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, I.R. Iran. 5Student Research Committee, Esfarayen Faculty of Medical Sciences, Esfarayen, I.R. Iran.


| Mahdi Esmaeilizadeh
6Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| Amir Hossein Jafarian
7Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| Ahmad Ghorbani


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1889
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955263.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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