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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۴۶-۱۵۴
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis
چکیده انگلیسی مقاله T helper (Th)-17 mediate inflammation in both peripheral tissues and the central nervous system. Signal transducer and activator of transcription factor3 (STAT3) is required for Th-cell pathogenicity and its activation in the brain has been demonstrated during the acute phase of experimental autoimmune encephalomyelitis (EAE) through the mammalian target of rapamycin (mTOR) signaling. Rapamycin (RAPA), an inhibitor of mTOR, can drive Forkhead box P3 (FOXP3 + ) induction as a regulatory factor. The aim of this study was to determine the effects of hemp seed/evening primrose oils (HSO/EPO) supplement on the expression of FOXP3 + , STAT3, and interleukin (IL)-17 genes in EAE lymph nodes. EAE was induced by myelin oligodendrocyte glycoprotein peptide in mice, and then the mice were assigned to three treatment groups compared to two control groups (EAE and naive). The histological findings of the spinal cord were evaluated. To determine the expression of FOXP3 + , STAT3, and IL-17 genes in the lymphocytes, qRT-PCR was used. Our results showed that EAE severity was reduced in HSO/EPO mice by reducing the expression of STAT3 and IL-17 genes and increasing the expression of FOXP3 + gene, which was confirmed by slight inflammation in the spinal cord. Histological findings showed a significant improvement in the HSO/EPO group. Our findings suggest that the HSO/EPO treatment can be used to ameliorate the demyelination of spinal cord, which was confirmed by immunological and histological findings.
کلیدواژه‌های انگلیسی مقاله Autoimmune,Encephalomyelitis,Lymphocytes,Rapamycin,T cell.
نویسندگان مقاله | Soheila Rezapour-Firouzi
2Solid Tumor Research Center, Urmia University of Medical sciences, Urmia, I.R. Iran.


| Fatemeh kheradmand
1Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, I.R. Iran.


| Sharam Shahabi
3Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, I.R. Iran.


| Ali Asghar Tehrani
1Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, I.R. Iran.


| Ebrahim Mazloomi
4Departement of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, I.R. Iran.


| Adel Mohammadzadeh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1890
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955264.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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