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گوارش، جلد ۲۱، شماره ۳، صفحات ۱۷۶-۱۸۴
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عنوان انگلیسی Relevance of Helicobacter Pylori Plasticity and cagPAI Regions Known Genes to Gastric and Duedenal Ulcers in Iran
چکیده انگلیسی مقاله Background: Helicobacter pylori ( H. pylori ) is the main cause of gastroduodenal diseases, such as chronic atrophic gastritis, gastric ulcer (GU), and duodenal ulcer (DU). There is a close relationship between H. pylori -specific factors and different gastroduodenal diseases. The aim of the present study was to clarify the roles of the plasticity region genes ( jhp0940 , jhp0945, and jhp0947 ) and the known genes of cag PAI ( cagA and cagE ) in relation to GU and DU diseases . Materials and Methods: A total of 173 strains that were isolated from 114 patients with non-atrophic gastritis (NAG), 30 patients with DU, and 29 patients with GU were genotyped. Data were collected and analyzed using SPSS software version 19. Results: The cagE gene had the highest frequency (69.4%) and jhp0945 had the least frequency (11.0%) among the genes. When GU was considered as a dependant factor in simple logistic regression analysis, no genotype correlation was found with risk for GU in Iran (P>0.05). Statistical analysis showed that cagA + and cagA + / jhp0940 + genotypes were significantly associated with an increased risk of DU but not GU. The Odds ratios (95% CI) were 3.143 (1.120-8.817), and 7.250 (1.493-38.199), respectively. Conclusion: Given the high frequency of cagE , this gene could be a suitable marker for the presence of cag PAI in Iranian strains. cagA + and cagA + / jhp0940 + genotypes can be beneficial biomarkers for risk prediction of DU in Iran.
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نویسندگان مقاله | Seyedeh Zahra Bakhti


| Shokofeh Gholizadeh


| Saeid Latifi-Navid


| Saber Zahri


| Farideh Feizi


| Abbas Yazdanbod


نشانی اینترنتی http://govaresh.org/index.php/dd/article/view/1545
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/141/article-141-1955635.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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