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Dental Research Journal، جلد ۵، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی Age-Dependent Changes of Salivary IgA and IgE Levels in Healthy Subjects
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: The secretory immunoglobulin A (IgA) is the first line of defense against pathogens that invade mucosal surfaces. It has been reported that the immune system exhibits profound age-related changes. The aim of this study was to investigate the age-dependent changes of salivary IgA and IgE levels among healthy subjects. Methods: Saliva samples were collected from 203 healthy individuals (aged 1-70 years). The salivary IgA and IgE concentrations were measured by use of ELISA technique and analyzed using the Mann-Whitney U, Kruskal-Wallis and Chi-Square tests. Results: The mean salivary IgA levels were 42.67 μg/ml  at age 1-10 years, 82.44 μg/ml at age 11-20 years, 93.5 μg/ml  at age 21-30 years, 97.58 μg/ml  at age 31-40 years, 106.45 μg/ml  at age 41-50 years, 113.47 μg/ml  at age 51-60 years and 92.95 μg/ml at age 61-70 years. There was significant difference among mean salivary IgA levels of different age groups (P Conclusion: These results showed that the salivary IgA and IgE levels exhibit age-related changes. Oral immunization may be considered to improve oral immunity when the salivary concentrations of IgA begin to decrease during lifetime.
کلیدواژه‌های انگلیسی مقاله Adult, immunoglobulin A, immunoglobulin E, saliva.
نویسندگان مقاله | Abdollah Jafarzadeh
Associate Professor, Department of Immunology and Biology Research Center , Kermanshah University of Medical Sciences, Kermanshah, Iran


| Ali Mostafaie
Associate Professor, Department of Operative Dentistry, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Mostafa Sadeghi
Bachelor of Science, Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Maryam Nemati
Bachelor of Science, Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Mohammad Taghi Rezayati
Assistant Professor, Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Gholamhossein Hassanshahi


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/56
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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