این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۱۳، شماره ۳، صفحات ۱۹۶-۲۰۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of Co-Administration of Bone Marrow Stromal Cells and L-Carnitine on The Recovery of Damaged Ovaries by Performing Chemotherapy Model in Rat
چکیده انگلیسی مقاله Objective: Chemotherapy may damage ovaries. L-carnitine (LC) as a type of flavonoid antioxidants and bone marrow stromal cells (BMSCs) as a type of mesenchymal stem cells may recover damaged ovaries. It seems that LC has favorable effects on differentiation, increasing lifespan and decreasing apoptosis in BMSCs. The aim of this study was to investigate the effects of co-administration of BMSCs and LC on damaged ovaries after creating a chemotherapy model with cyclophosphamide in the rat. Materials and methods: In this experimental study, BMSCs were cultured and were confirmed by CD markers of stromal cells. Forty female Wistar rats were injected intraperitoneally with cyclophosphamide for 14 days for induction of chemotherapy and ovarian destruction. Then, the rats were randomly divided into four groups: control, LC, BMSCsthe and co-administration of LC and BMSCs. Injection of BMSCs into bilateral ovaries and intraperitoneal injection of LC were performed individually and together. Four weeks later, the levels of serum E2 and FSH using ELISA reader, the number of ovarian follicles at different stages using H&E staining, and the expression of ovarian Bcl-2 and Bax proteins using western blot were assessed. Results: The results showed that the effects of co-administration of BMSCs and LC were significantly more favorable than the control, BMSC and LC groups on the recovery of damaged ovaries (P< 0.05). Conclusion: The effect of co-administration of BMSCs and LC is probably more effective than the effect of their separate administration on the recovery of damaged ovaries by chemotherapy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Sam Zarbakhsh


| Robabeh Safari


| Hamid Reza Sameni


| Behpour Yousefi


| Manouchehr Safari


| Nasrin Khanmohammadi


| Parisa Hayat


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5725
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-1956309.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات