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International Journal of Radiation Research، جلد ۱، شماره ۳، صفحات ۱۵۷-۱۶۱
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عنوان انگلیسی [66Ga]Oxine complex preparation and stability as a possible PET radiopharmaceutical.
چکیده انگلیسی مقاله Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the 66Zn(p,n)66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. Results: After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% (radiochemical purity > 98%). The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml. Conclusion: [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo. Iran . J. Radiat. Res., 2003 1(3): 157 - 161
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نویسندگان مقاله a r جلیلیان | a r jalilian
cyclotron nuclear medicine dept - research center for agriculture and medicine, karaj, iran


p rowshanfarzad | p rowshanfarzad
ion beam application dept - research center for agriculture and medicine, karaj, iran


a رحیمی نژاد | a rahiminejad


a a رجامند | a a rajamand


a j نوین روز | a j novinrooz


نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-23&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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