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Middle East Journal of Digestive Diseases، جلد ۱۱، شماره ۴، صفحات ۲۰۰-۲۰۵
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چکیده فارسی مقاله
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عنوان انگلیسی Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis
چکیده انگلیسی مقاله BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a member of the immunoglobulin superfamily, which binds B7-1 and B7-2 on APCs (antigen-presenting cells), and induces APCs to produce an inhibitory signal to T cells. The aim of this study was to investigate the effect of vitamin D on CTLA-4 gene expression in whole blood samples of patients with UC. METHODS: 90 patients with mild to moderate UC were randomized to receive either a single injection of 7.5 mg vitamin D3 or 1 mL normal saline. 90 days following the intervention fold changes in CTLA-4 mRNA expression were determined and statistical comparisons between the two groups were performed. RESULTS: Serum vitamin D increased significantly only in the vitamin D group. CTLA-4 fold changes were significantly higher in the vitamin D group compared with the placebo group (median±IQR: 1.21±2.3 vs. 1.00±1.5, respectively; p =0.007). CONCLUSION: The results of this study revealed that vitamin D administration in patients with UC enhances the CTLA-4 gene expression. KEYWORDS: Ulcerative colitis; inflammatory bowel disease; CTLA-4; Vitamin D; Gene expression
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Amrollah Sharifi
Digestive Disease Research Center, Digestive Research Institute, Shariati ‎Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Homayoon Vahedi
Health Management and Social Development Research Center, Faculty of health, Golestan University of Medical Sciences, Gorgan, Iran.


| Mohammad Reza Honarvar
Department of laboratory sciences, faculty of paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran.


| Behnam Alipoor
Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Zeinab Nikniaz
Faculty of Health and Social Development, College of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.


| Hossein Rafiei
Department of Clinical Nutrition, School of Nutritional Sciences and ‎Dietetics, Tehran University of Medical Sciences, Tehran, Iran.


| Mohammad Javad Hosseinzadeh-Attar


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2079
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/332/article-332-1989744.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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