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Iranian Biomedical Journal، جلد ۲۴، شماره ۱، صفحات ۱-۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Potential Vaccines for Treating Crohn's Disease
چکیده انگلیسی مقاله Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) tract and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium paratuberculosis in CD. Apart from different therapeutic approaches for treating CD, development of a vaccine is a novel modality. In the present article, most available therapeutic opportunities in the last decade, especially the possibility of vaccines against CD, are reviewed. According to search, availability of a new generation of vaccines against CD is expected specially tolerogenic ex vivo-derived dendritic cell-based vaccines. Regarding different locations of the challenge and the variety of clinical manifests of CD and also the type of resident antigen-presenting cells and their traffic in different parts of gastrointestinal tract, the results of immunotherapy with dendritic cell-based vaccines may vary case by case.
کلیدواژه‌های انگلیسی مقاله Crohn’s disease, Inflammatory bowel diseases, Vaccines
نویسندگان مقاله | Mohammad Rostami-Nejad
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Hossein Yazdi
Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Shekoufeh Nikfar
Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran


| Ali Rezaie
Cedars-Sinai Medical Center, Los Angeles, CA, USA


| Mohammad Abdollahi
Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-795&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-2017329.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Immunology & Vaccines
نوع مقاله منتشر شده مقاله مروری
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