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Acta Medica Iranica، جلد ۵۷، شماره ۶، صفحات ۳۴۲-۳۴۷
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عنوان انگلیسی The correlation between plasma levels of vitamin D and epigenetic alterations of Treg-Specific Demethylated Region (TSDR) in Rheumatoid Arthritis patients
چکیده انگلیسی مقاله Background: Rheumatoid arthritis (RA) is the most common autoimmune inflammatory disease of joints among adults. Regulatory T cells (Treg) control immune responses in this illness. Through the expression of FoxP3, a Treg transcription factor, Vitamin D keeps autoimmune diseases in check. Yet, the molecular mechanism of FoxP3 expression by vitamin D is not well-inspected. It may influence FoxP3 expression via epigenetic changes. This study aimed to investigate the correlation between plasma levels of vitamin D and the demethylation of TSDR region in Foxp3 promoter in patients with RA. Methods: Twenty untreated RA patients and 41 healthy controls participated in this study. Plasma levels of 25-OH vitamin D were measured by competitive ELISA method. The demethylation of TSDR regions in Foxp3 gene was also assessed using the quantitative Methylation Specific PCR (qMSP) method. Results: The demethylation of TSDR region was significantly lower in RA patients compared with healthy controls (P=0.006). Vitamin D plasma levels were significantly higher in RA patients rather than healthy people (P=0.034). There was no statistically significant correlation between vitamin D plasma levels and demethylation of TSDR region. Conclusion: As expected, epigenetic alternation showed considerable difference between RA patients and healthy control but about vitamin D correlation with methylation modification, more studies are needed to be carry out.
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نویسندگان مقاله | Mahdi Taghadosi
1- Assistant Professor in Department of Immunology, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Soraya Bilvayeh
2- Student Research Committee, Medical school, Kermanshah University of Medical Sciences, Kermanshah, Iran
 3- Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Sasan Ghaffari
4- Hematology Department, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran.
 5- Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Nasrin Iranshahi
2- Student Research Committee, Medical school, Kermanshah University of Medical Sciences, Kermanshah, Iran
 3- Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Parisa Zafari
2- Student Research Committee, Medical school, Kermanshah University of Medical Sciences, Kermanshah, Iran
 3- Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Amirreza Esfandiari
2- Student Research Committee, Medical school, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7625
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