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Acta Medica Iranica، جلد ۵۷، شماره ۶، صفحات ۳۵۵-۳۵۸
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عنوان انگلیسی Dexmedetomidine versus ketamine combined with fentanyl for sedation-analgesia in colonoscopy procedures: a randomized prospective study
چکیده انگلیسی مقاله     Abstract   Background: Colonoscopy is a painful, embarrassing and short-term procedure that needs temporary sedation and rapid recovery. The aim of this study was to compare the sedation and analgesic effect and hemodynamic changes due to bolus intravenous injection of dexmedetomidine and ketamine during elective colonoscopy. Methods: This clinical trial was conducted on 70 patients aged 20 - 70 years, candidates for elective colonoscopy, who randomly divided into two equal groups. For all patients 0.03mg/kg midazolam  10 min before procedure was injected. Fentanyl  1 µ /kg was administrated in both group 5 min before procedure and one min before colonoscopy  K group received 0.5mg/kg ketamine  and D group received  1 µ/kg dexmedetomidine.  Then, the normal saline infusion was used as maintenance. Fentanyl 25-50 µg was prescribed as the rescue dose if needed during the procedure. Hemodynamic changes,  sedation level during procedure , patients and  colonoscopiest satisfaction were recorded in recovery. Results: the mean heart rate and mean blood pressure was significantly less in the dexmedetomidine group than in the ketamine group . All of the patients in the ketamine group were deep to moderate sedated during colonoscopy and  the amount of fentanyl required in this group is much less than dexmedetomidine group(68.02±25.63 vs 91.45±38.62 µg  p-0.003). In terms of satisfaction, only 42% of patients in the dexmedetomidine group were complete satisfied with colonoscopy while 65% of Ketamine group had complete satisfaction with colonoscopy (p=0.001). In terms of satisfaction, only 42% of patients in the Dexmedetomidine group were complete satisfied with colonoscopy while 65% of Ketamine group had complete satisfaction with colonoscopy (p=0.001). Conclusion: In patients undergoing colonoscopy IV blouse injection of  dexmedetomidine in compare with ketamine provide less satisfactory level of sedation with supplemental multiple doses of fentanyl during the procedure.  Keywords: Sedation, Colonoscopy, Dexmedetomidine, Ketamine, Satisfaction                  
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نویسندگان مقاله | mohammad khajavi
Tehran University of Medical Sciences
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/8054
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2047125.pdf
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