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Acta Medica Iranica، جلد ۵۷، شماره ۶، صفحات ۳۵۹-۳۶۲
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عنوان انگلیسی Amniocentesis following positive first trimester combined screening : A comparative study
چکیده انگلیسی مقاله Introduction: The birth of a neonate with chromosomal abnormalities e.g. Down syndrome has very serious problems for family, society and for the neonate itself and therefore prenatal evaluation is imperative in determining the fate of the fetus. This research aims to assess the association and accuracy of amniocentesis with first trimester combined screening .    Materials and Methods:  In this study, specimens from 1066 cases were analyzed for free Beta human chorionic gonadotropin, pregnancy associated plasma protein A, along with nuchal translucency and nasal bone ultrasonography from October 2013 till November 2014. Upon observing positive screening, mothers underwent amniocentesis. Finally the amniocentesis results were compared with that of first trimester screening.   Results: Our results determined a direct relation between the high age of the mother and gravidity with P.value of 0.001 and 0.020 with positive first trimester screening.  Our study attained a 92% accuracy rate of amniocentesis due to one case of mosaicism of trisomy 21, that was not diagnosed, because it was not requested by physician.. Only 12(17.1%) cases out of 70 (mothers with positive first trimester screening) showed positive amniocentesis which had a significant relationship with chromosomal abnormality.   Conclusion: First trimester combined screening have very high accuracy (94.6%) in prediction of genetic abnormalities. The probability of positive first trimester screening is directly influenced by number of factors including the mother age and gravidity. Amniocentesis is necessary for all of mothers with positive first trimester screening and will almost always detect chromosomal abnormalities.   Key Words: Pregnancy first trimester , Amniocentesis , Prenatal diagnosis
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نویسندگان مقاله | Fakhrolmolouk Yassaee
Shahid Beheshti University of Medical Sciences


| Reza Shekarriz-Foumani


| Shima Sadeghi


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7769
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2047126.pdf
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