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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱، صفحات ۳-۱۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Role of crocin in several cancer cell lines: An updated review
چکیده انگلیسی مقاله Cancer is a major public health problem worldwide. The most important considerable features of cancer cells are uncontrolled proliferation, up-regulated differentiation, and immortality. Crocin, as a bioactive compound of saffron and as a water-soluble carotenoid has radical scavenging, anti-hyperlipidemia, memory improving, and inhibition of tumor growth effects. The present review was designed to evaluate molecular mechanisms underlying crocin effects against cancer cell lines. Data of this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, and Scientific Information Database from 1982 to 2019. According to various literature, crocin inhibits tumor growth, and its spread in several types of cancer including colorectal, pancreatic, breast, and prostate, as well as chronic myelogenous and leukemia. It inhibits telomerase activity, microtubule polymerization, cyclin D1, nuclear factor kappa B (NF-kB), multidrug resistance-associated protein (MRP1), and MRP2 overexpression. Crocin can induce apoptosis through activation of caspase 8, up-regulation of p53 expression, Bax/Bcl-2 ratio, and down-regulation expression of Bcl-2, survivin, and cyclin D1. It also down-regulates matrix metalloproteinase 2 and 9 (MMP2 and MMP9), N-cadherin, and beta-catenin expression, which are involved in tumor invasion and metastasis. Tumor invasion was also inhibited by crocin through increasing E-cadherin expression, cell cycle suppression at G1, G0/G1, S, and G2/M phases. Crocin has therapeutic and preventive effects on cancer cells line. Therefore, it has been suggested that this agent can be administered in patients that suffer from this problem.
کلیدواژه‌های انگلیسی مقاله Cancer, Cell line, Crocin, Review, Tumor
نویسندگان مقاله | Ali Veisi
Behbahan Faculty of Medical Sciences, Behbahan, Iran


| Ghaidafeh Akbari
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran


| Ali Mard
Research Center for Infectious Diseases of Digestive System [Alimentary Tract Research Center], Physiology Research Center (PRC), Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Gholamreza Badfar
Department of pediatrics, Behbahan Faculty of Medical Sciences, Behbahan, Iran


| Vahid Zarezade
Behbahan Faculty of Medical Sciences, Behbahan, Iran


| Mohammad Ali Mirshekar
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14236.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2060532.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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