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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱، صفحات ۷۹-۸۵
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عنوان انگلیسی Exercise training attenuates diabetes-induced cardiac injury through increasing miR-133a and improving pro-apoptosis/anti-apoptosis balance in ovariectomized rats
چکیده انگلیسی مقاله Objective(s): The useful and effective role of exercise program to prevent cardiac tissue apoptosis and fibrosis in ovariectomized type 2 diabetic (T2DM) rats (OVR.D) is well known. The current study aimed to investigate the simultaneous effects of T2DM and swimming plan on the expression of some apoptotic, anti-apoptotic biomarkers and glycogen changes in the cardiac muscle tissue of ovariectomized (OVR) rats.Materials and Methods: Forty rats were randomly sorted into 4 equal categories; sham, OVR, OVR.D and diabetic ovariectomized with an 8 week of swimming plan (OVR.D.E). Lipid profile and miR-133, Bcl-2, Bax, caspase-3 and caspase-8 levels were evaluated in the cardiac tissue.Results: Ovariectomy significantly (P-value
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Parisa Habibi
Neurophysiology research center, Hamadan University of Medical Sciences, Hamadan, Iran


| Alireza Alihemmati
Department of Histology & Embryology, Tabriz University of Medical Sciences, Tabriz, Iran


| Nasser Ahmadiasl
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Abolfazl Fateh
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran


| Enaiat Anvari
Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14087.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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