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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱، صفحات ۹۳-۱۰۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Chronic consumption of cassava juice induces cellular stress in rat substantia nigra
چکیده انگلیسی مقاله Objective(s): Cassava (Manihot esculenta Crantz) contains cyanogenic glycosides (linamarin and lotaustralin) that have been associated with neurological disorders in humans and rats. In basal ganglia, the dopaminergic neurons of substantia nigra pars compacta (SNpc) show high cytotoxic susceptibility; therefore, the chronic consumption of cassava (CCC) could induce neurodegeneration in SNpc. In this study we examine the impact of CCC on the integrity of the nigrostriatal system, including apoptosis and microgliosis. Materials and Methods: Male Wistar rats were administered cassava juice daily (3.57 g/kg and 28.56 g/kg, per os) or linamarin (0.15 mg/ml, IP), and its effects were evaluated in rota-rod and swim tests at days 7, 14, 21, 28, and 35 of administration. In SNpc, oxidative/nitrosative stress was determined by malondialdehyde/4-hydroxyalkenals (MDA-4-HAD) and nitrite contents. Tyrosine hydroxylase immunoreactivity (TH-IR) was evaluated in SNpc, neostriatum (NE), and nucleus accumbens (NA). Apoptosis and microgliosis were determined by active-caspase-3 (C3) and CD11b/c (OX42) expression in the medial region of SNpc. Results: Chronic administration of cassava juice, or linamarin, increased motor impairment. The rats that received 28.56 g/kg cassava showed increased MDA-4-HAD content in SNpc and nitrite levels in NE with respect to controls. Significant loss of TH-IR in SNpc, NE, and NA was not found. The 28.56 g/kg cassava administration produced dopaminergic atrophy and microgliosis, whereas linamarin induced hypertrophy and C3-related apoptosis in SNpc. Conclusion: CCC induces cellular stress on dopaminergic neurons, which could contribute to motor impairment in the rat.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Inflammation, Hypertrophy, Manihot, Survival
نویسندگان مقاله | Christian de Jesús Rosas-Jarquín
Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana. Xalapa, Veracruz. Mexico


| Eduardo Rivadeneyra-Domínguez
Facultad de Química Farmacéutica Biológica, Universidad Veracruzana. Xalapa, Veracruz. Mexico


| Bertha Alicia León-Chávez
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla. Puebla, Puebla. Mexico


| Rasajna Nadella
IIIT Srikakulam, Rajiv Gandhi University of Knowledge Technologies (RGUKT); International collaboration ID: 1840; India


| Aurora del Carmen Sánchez-García
Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”. Ciudad de México. Mexico


| Daniel Rembao-Bojórquez
Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”. Ciudad de México. Mexico


| Juan Francisco Rodríguez-Landa
Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz. Mexico


| Daniel Hernandez-Baltazar
CONACyT-Instituto de Neuroetología, Universidad Veracruzana. Xalapa, Veracruz. Mexico
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14198.html
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