این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۱۲، صفحات ۱۴۰۸-۱۴۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats
چکیده انگلیسی مقاله Objective(s): Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex proteins are involved in membrane trafficking. The expression of isoforms of SNAP-23, syntaxin-4, and VAMP-2 is significantly done in skeletal muscles; they control GLUT4 trafficking. It is believed that type 2 diabetes could be caused by the modifications in the expression of SNARE complex proteins. The purpose of this study was to evaluate the effect of resveratrol on the expression of these proteins in type 2 diabetes.Materials and Methods: Forty male Wistar rats were selected. Streptozotocin and nicotinamide were applied for the induction of type 2 diabetes. The animals were divided into five groups. Healthy and diabetic groups were set as control; resveratrol (1, 5, and 10 mg/kg body weight) was applied to treat the three groups of diabetic rats for 30 days. Real-time qRT-PCR was applied to evaluate the expression of SNARE complex proteins.Results: There is a link between diabetes and insulin resistance and up-regulation of SNARE proteins expression. Resveratrol improved hyperglycemia and insulin resistance along with a non-significant reduction in the expression of SNARE proteins.Conclusion: Increased expression of SNARE proteins was possibly a compensatory mechanism in response to insulin resistance in the skeletal muscles of diabetic rats. Resveratrol non-significantly reduced the expression of SNARE proteins by enhancing insulin sensitivity, where this effect was dose-dependent. Thus, higher doses of resveratrol and longer intervention periods could probably be more effective. Another molecular mechanism of the anti-diabetic properties of resveratrol was identified with an effect on the expression of SNARE proteins.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Azam Rezaei Farimani
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran|Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Mohammad Taghi Goodarzi
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Massoud Saidijam
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Reza Yadgar Azari
Department of Molecular Medicine and Genetics, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran


| Sadegh Zarei
Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


| Soheila Asadi
Department of Clinical Biochemistry, Facultyl of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_13988.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2060554.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات