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Iranian Journal of Pathology، جلد ۱۴، شماره ۴، صفحات ۳۲۹-۳۳۷
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عنوان انگلیسی Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection
چکیده انگلیسی مقاله Background & Objective: Diabetic foot ulcer (DFU), is one of the most frequent causes for hospitalizations in patients with diabetes. A major problem in the treatment of DFU is the increased-incidence of methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to determine the SCCmec types of MRSA isolates and their epidemiology among patients with diabetes. Methods: This study was carried out on 145 diabetic patients with DFUs. The antibiotic susceptibility tests (ASTs) were performed using the disk diffusion method and E-test technique. SCCmec typing was done by multiplex PCR. Moreover, the presence of virulence toxin genes, including pvl and lukED was detected by PCR assay. Results: In 145 samples from which S. aureus was predominantly isolated, 19.48% were MRSA. Analysis of MRSA isolates revealed that the most prevalent SCCmec type was type IV (46.7%) followed by type III (30.0%) and type V (20.0%). One strain (3.3%) was untypeable. The prevalence of pvl and lukED was 56.7% and 100%, respectively. Conclusion: The high prevalence of MRSA in DFUs represents the high levels of antibiotic usage among patients with diabetes. In this study, resistance to other important clinical antibiotics was detected among MRSA isolates. The high proportion of SCCmec type IV and V strains, even in former hospitalized patients, indicates the entrance of these clones to the clinical setting.
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نویسندگان مقاله Pegah Kananizadeh |
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Solmaz Ohadian Moghadam |
Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Yasaman Sadeghi |
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Abbas Rahimi Foroushani |
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science. Tehran, Iran

Hossein Adibi |
Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences. Tehran, Iran

Mohammad Reza Pourmand |
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://ijp.iranpath.org/article_36662_add6111a1d1590a50667ab6cf5340469.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-2060754.pdf
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