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Basic and Clinical Neuroscience، جلد ۱۰، شماره ۵، صفحات ۱-۱
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عنوان انگلیسی Protective Effects of Nucleobinding-2 After Cerebral Ischemia Via ‎Modulating Bcl-2/Bax Ratio and Reducing Glial Fibrillary Acid Protein ‎Expression
چکیده انگلیسی مقاله Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemia-reperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. This study was designed for the first time to investigate the protective effects of NUCB2/Nesfatin-1 on the expression of apoptosis-related proteins and reactive astrogliosis level in the CA1 area of hippocampus in an experimental model of transient global cerebral ischemia. Methods: The male Wistar rats were randomly allocated into 4 groups (sham, NUCB2, ischemia-reperfusion, and ischemia-reperfusion+NUCB21) (n = 7). The model of cerebral ischemia was prepared by common carotid arteries occlusion for 20 minutes. Nesfatin-1 (20 µg/kg) and saline (as a vehicle) were injected (intraperitoneally) at the beginning of the reperfusion period. The assessment of the protein expression levels was performed by immunofluorescence and immunohistochemical staining. Results: NUCB2 significantly reduced the Bax and GFAP protein levels in the CA1 area after ischemia (P< 0.05). Also, NUCB2 increased Bcl-2 protein level (P< 0.05). NUCB2 exerted protective effects against ischemic injury by the inhibition of astrocytes activation as an inflammatory response and decreased neuronal cell apoptosis. Conclusion: The present study provides the possible neuroprotective view of nesfatin-1 in the treatment of ischemia injury model in rat hippocampus.  [MA1]Or nucleobindin-2? Check it please.
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نویسندگان مقاله | Soheila Erfani
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran


| Ali Moghimi
Rayan Center for Neuroscience and Behavior, Department of Biology, Faculty of Science, ‎Ferdowsi University of Mashhad, Mashhad, Iran


| Nahid Aboutaleb
Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran ‎University of Medical Sciences, Tehran, Iran.;Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, ‎Iran


| Mehdi Khaksari
Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-135-3&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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