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Avicenna Journal of Phytomedicine، جلد ۹، شماره ۶، صفحات ۴۹۱-۴۹۸
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کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The mechanism of neuroprotective effect of Viola odorata against serum/glucose deprivation-induced PC12 cell death
چکیده انگلیسی مقاله Objective: Oxidative stress is associated with the pathogenesis of brain ischemia and other neurodegenerative disorders. Previous researches have shown the antioxidant activity of Viola odorata L. In this project, we studied neuro-protective and reactive oxygen species (ROS) scavenging activities of methanol (MeOH) extract and other fractions isolated from V. odorata in PC12 cell line in serum/glucose deprivation (SGD) condition. Materials and Methods: The PC12 neuronal cells were pretreated for 6 hr with MeOH extract and fractions of V. odorata (1 to 25 μg/ml) followed by 24 hr incubation under SGD condition. Cell viability was measured by Alamar Blue® assay. The level of ROS was calculated using DCFH-DA. Also, Bax/Bcl-2 protein ratio was analyzed by western blot assay. Results: SGD condition significantly decreased cells viability (p
کلیدواژه‌های انگلیسی مقاله Viola odorata, Violaceae, PC12 cells, ROS, SGD
نویسندگان مقاله | Zahra Tayarani Najjaran
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.


| Rezvan Yazdian
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.


| Elaheh Amini
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.


| Farzaneh Salek_Abdollahi
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


| Fatemeh Arasteh
Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Ahmad Emami
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی http://ajp.mums.ac.ir/article_13098.html
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short communication
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