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Avicenna Journal of Phytomedicine، جلد ۹، شماره ۶، صفحات ۵۸۷-۵۹۶
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چکیده فارسی مقاله
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عنوان انگلیسی Zataria multiflora Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats
چکیده انگلیسی مقاله Objective: Zataria multiflora (Zm) has been proposed for memory enhancing in Persian traditional medicine; but to now, no study has been carried out in this field yet. The aim of this research was to study the plant effect on spatial memory in scopolamine-induced amnesia and investigate in vivo anticholinesterase effect of Zm. Material and Methods: Aerial parts of the plant were extracted with methanol and standardized on the basis of rutin content. Male rats received three doses of Zm extract (100, 200 and 400 mg/kg, intraperitoneal (ip) for 7 days) and 30 min after the latest dose, scopolamine (1 mg/kg) was administered to animals. Learning capacity and spatial memory were studied using morris water maze (MWM) and passive avoidance test (PAT) methods. Anticholinesterase activity was studied using Ellman’s method. Physostigmine (0.3 mg/kg) and piracetam (200 mg/kg) were used as positive controls. Results: All doses of Zm extract significantly decreased the distance and time spent to find the platform in MWM and increased the time latency in PAT test. In both MWM and PAT tests, the highest effect of Zm was observed at 200 mg/kg which was in accordance with AChE inhibitory effect of the plant. Conclusion: Our findings indicate that Zm has anti-amnesic effect and might improve memory deficit through anticholinesterase activity.
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نویسندگان مقاله | Vahid Sheibani
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.


| Ali Mandegary
Pharmaceutical Research Center, Neuroscience Institute, Department of Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.


| Elham Vazifekhahan
Herbal and Traditional Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.


| Zahra Kasbzade
Herbal and Traditional Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.


| Amir Asadi
Herbal and Traditional Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.


| Fariba Sharififar
Herbal and Traditional Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
نشانی اینترنتی http://ajp.mums.ac.ir/article_13540.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2060812.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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