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Avicenna Journal of Phytomedicine، جلد ۹، شماره ۶، صفحات ۵۹۷-۶۰۵
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عنوان انگلیسی Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats
چکیده انگلیسی مقاله Objective: In the present study, we aimed to examine the effect of troxerutin treatment on levels of brain-derived neurotrophic factor (BDNF), and tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), as pro-inflammatory cytokines, in the blood and hippocampus of high-fat diet (HFD) fed dams and their male offspring. Materials and Methods: Forty virgin female Wistar rats, 3 weeks old, were divided into two groups (n=20/per group) and fed control diet (CD), or HFD for 8 weeks. After mating, pregnant animals were assigned to four subgroups including: control (CD), control+troxerutin (CD+T), high-fat diet (HFD), and HFD+troxerutin (HFD+T) groups. HFD was continued during pregnancy and lactation. Troxerutin (150 mg/kg/day, P.O.) was administered during pregnancy in the CD+T and HFD+T groups. On postnatal day (PND) 21, male offspring were separated and fed a normal diet until PND 90. Inflammatory cytokines (TNF-α, and IL-6) and BDNF levels were measured in the serum and hippocampal samples using rat-specific enzyme-linked immunosorbent assay (ELISA) kits. Results: Our findings showed a significant increase in the serum levels of TNF-α and IL-6, but a decrease in BDNF levels in the serum of HFD-fed dams in comparison with CD group, which was reversed by troxerutin. Moreover, troxerutin treatment, during pregnancy, significantly decreased TNF-α and IL-6 levels, but increased BDNF level in the serum and hippocampus of HFD+T offspring in comparison with HFD offspring. Conclusion: These results showed that troxerutin could prevent the harmful effects of maternal HFD on their offspring through inhibition of pro-inflammatory cytokines and elevation of BDNF levels.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Maryam Hoseindoost
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Mohammad Reza Alipour
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Fereshteh Farajdokht
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Roghayeh Diba
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Parvin Bayandor
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Keivan Mehri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Sepehr Nayebi Rad
Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Shirin Babri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
نشانی اینترنتی http://ajp.mums.ac.ir/article_13587.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2060813.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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