این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Bulletin of Emergency and Trauma، جلد ۲، شماره Issue ۴، صفحات ۱۶۱-۱۶۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effects of Oltipraz on Tissue Regeneration in the Process of Wound Healing: A Stereological Study
چکیده انگلیسی مقاله Objective: To determine the effects of topical administration of 20% oltipraz solution on histomorphometrical and stereological aspects of skin tissue in full thickness skin wounds in laboratory rats.Methods: Thirty-six male Wistar portion rats (220±20 g) were randomly divided into three groups (n=12). On the first day of experimentation, a 1-cm2 circular wound was made on the posterior surface of neck in all rats by removing a full thickness skin piece immediately after induction of anesthesia with ether inhalation. One group was treated with vehicle solution (DMSO alone). The second group was treated daily with 20% oltipraz solution, and the third group, the control group, received no treatment. The wound closure rate was estimated our previously described method. The volume density of collagen bundles, vessels, and hair follicles, the vessels’ length density, mean diameter of vessels and also fibroblast population were estimated by using stereological methods.Results: The oltipraz group indicated a significantly higher improvement (6.26% of the wound surface per day) than control and the vehicle treated groups (p=0.032); furthermore, there was inconsiderable difference between the rate of wound closure in the group treated with vehicle (4.93% per day) and the control group (4.43% per day).Conclusion: Oltipraz has positive influence on fibroblast proliferation and re-epithelization. A noticeable observation in our study was absence of scar formation in wounds which were treated by oltipraz and can be mentioned as an advantage of this drug.
کلیدواژه‌های انگلیسی مقاله Oltipraz,Wound healing,Stereology,Rat
نویسندگان مقاله Ali Noorafshan |
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Sina Kardeh |
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Soheil Ashkani-Esfahani |


Mohammadreza Namazi |
Advanced trainee, Liverpool Hospital Dermatology Department, Liverpool, NSW, Sydney

Ehsan Saleh |
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی http://beat.sums.ac.ir/article_44273_d41f3d83ef6afed2e3b406ac36f818c2.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/271/article-271-2061078.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات