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Nanomedicine Journal، جلد ۶، شماره ۴، صفحات ۳۲۱-۳۲۸
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عنوان انگلیسی Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum
چکیده انگلیسی مقاله Objective(s): With no substantial cost, we injected L-arginine into the rat’s corpus callosum (CC) to create animal model of multiple sclerosis (MS) and investigated the pre-injection effect of gold nanoparticles (GNPs). Materials and Methods: Adult male Wistar rat (250-300 g) was surgically cannulated at the CC, and after recovery it was injected L-arginine (3-200 µg/rat, intra-CC) once daily for 3 to 5 consecutive days. GNPs (0.001-0.01 µg/rat, intra-CC) were injected alone or prior to the L-arginine using the same procedure. Control group solely received saline (1 µL/rat, intra-CC). Brain was studied with luxol fast blue. Weight change was also analyzed via the analysis of variance (ANOVA). Results: L-arginine significantly induced (p< 0.05) a reduction in the fiber density while the neurons increased (p< 0.05). Single GNPs reduced (p< 0.05) the fiber and neuron densities; however, pre-injection of NPs caused myelinated fibers and uniform density of neurons. Conclusion: The L-arginine may trigger demyelination by pro-inflammatory nitric oxide (NO), and the GNPs may improve this effect.
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نویسندگان مقاله | Mahjabin Khosravi
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran


| Manizheh Karami
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran


| Mohammadreza Jalali Nadoushan
Department of Pathology, Faculty of Medicine, Shahed University, Tehran, Iran


| Abazar Hajnorouzi
Department of Physics, Faculty of Basic Sciences, Shahed University, Tehran, Iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_13308.html
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زبان مقاله منتشر شده en
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