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Iranian Journal of Chemistry and Chemical Engineering، جلد ۳۸، شماره ۳، صفحات ۱۰۷-۱۱۶
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عنوان انگلیسی Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite
چکیده انگلیسی مقاله BXFL (bagasse xylem ferulate)-g-AM (acrylamide)/MAA (methyl methacrylate) was synthesized based on bagasse xylan(BX)-g-AM/MAA in 1-Butyl-3-methylimidazolium chloride ([Bmim] Cl) ion solution with Ferulic Acid (FL) as esterification agent. The various factors that were investigated influenced carboxylic acid ester substitution degree (DSC) of BXFL-g-AM/MAA. The structures of BXFL-g-AM/MAA were confirmed by IR, SEM and 1H NMR analysis. The cytotoxicity of BXFL-g-AM/MAA was investigated against twelve kinds of protein through Surflex-Dock Mode of Sybyl-X 2.0 software, and on three kinds of human cancer cells line and the human normal cells line were detected by MTT assay. It was shown that the maximum DSC was 1.09 in ion solution, which was superior to DSC of conventional method in organic solvent. The results of MTT assay were consistent with docking results. BXFL-g-AM/MAA exhibited relative high cytotoxicity against human gastric cancer cells (MGC-803) line.
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نویسندگان مقاله Kai Zuo |
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINA

Jingxia Qian |
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINA

Jun Gong |
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINA

Jun Zhang |
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINA

Heping Li |
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINA

Guoyong Zhou |
School of Chemistry and Eco-Environmental Engineering (School of Chinese Pharmacy), Guizhou Minzu University, Guiyang 550025, Guizhou, P.R. CHINA

نشانی اینترنتی http://www.ijcce.ac.ir/article_34238_cc5f52b2c134d1afc1eb4d44d8163209.pdf
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