این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Nanostructures، جلد ۹، شماره ۳، صفحات ۵۶۳-۵۷۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Investigation of The Effect of Radiosensitization of Tungsten Oxide Nanoparticles on AGS Cell Line of Human Stomach Cancer in Megavoltage Photons Radiation
چکیده انگلیسی مقاله Radiotherapy which consists of external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT), has a wide usage for treating cancer as clinical trials.This study provides some conditions to prove that tungsten oxide nanoparticles (WO3) is a radiosensitizer.The peripheral blood mononuclear cells (PBMCs) were used to calculate inhibitory concentration (IC).The AGS cell line exposed the concentration of 89.6 µg/mL (IC20) nanoparticle WO3 that was optimal and its radiosensitization was examined in megavoltage photons radiation of 6 MV x-rays. The sensitivity enhancement ratio (SER) and dose enhancement factor (DEF) was determined 1.24 and 1.68 respectively. We described the mechanisms of creating nanoparticles WO3 toxicity and genotoxicity in different concentrations on AGS cell line. The mean size of WO3 NPs by transmission electron microscopy wasmeasured 31.89 3.82 nm.Tungsten oxide Nanoparticles cause to reduce cell viability, remove membrane and damage to DNA. There was a meaningful increasing in damages to DNA and proliferation cell potency and also significantly reducing cell viability in concentrations more than 100 µg/mL.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله Amin Hassanvand |
Department of Medical Physics, Faculty of Medicine,Shahid Sadoghi University of Medical Sciences,Yazd, Iran

Mohammad Hossein Zare |
Department of Medical Physics, Faculty of Medicine,Shahid Sadoghi University of Medical Sciences,Yazd, Iran

Ali Shams |
Department of Immunology, Faculty of Medicine, Shahid Sadoghi University of Medical Sciences, Yazd, Iran

Abolfazlal Nickfarjam |
Department of Medical Physics, Faculty of Medicine,Shahid Sadoghi University of Medical Sciences,Yazd, Iran

Masood Shabani |
Department of Radiation therapy-Oncology, Faculty of Medicine,Shahid Sadoghi University of Medical Sciences,Yazd, Iran

Hossein Rahavi |
Department of Immunology, Faculty of Medicine, Shahid Sadoghi University of Medical Sciences, Yazd, Iran

نشانی اینترنتی http://jns.kashanu.ac.ir/article_84392_dc6de7a5469cc5dcbe9d96a4f1ead9f9.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/497/article-497-2063376.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات