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Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۱، صفحات ۷۰-۷۷
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors
چکیده انگلیسی مقاله Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. Material and Methods: The hydro-alcoholic extract (HAE) of T. parthenium and three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and n-hexane fraction (NHF), were intraperitoneally (ip) administrated to mice 30 min before injection of sodium pentobarbital (30 mg/kg, ip). Then, 30 min after administration of HAE, motor coordination (rota-rod test) was evaluated. Besides, LD50 of HAE was determined and the cytotoxicity of HAE was evaluated in PC12 cells using the MTT assay. Results: HAE 50-200 mg/kg increased the sleeping time. EAF was the only fraction which could prolong the sleep duration and decrease sleep latency. The LD50 value was 4.8 g/kg. The extract induced no cytotoxic effects in PC12 cell line. Conclusion: The results suggested that T. parthenium potentiates pentobarbital hypnosis without causing toxic effects. Probably, its effects are mediated by the components present in EAF of this plant.
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نویسندگان مقاله | Fatemeh Forouzanfar
Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Hamed Ghazavi
Department for Population and Family Health, Vice Chancellery for Health, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammad Mahdi Vahedi
Health Promotion Research Center, Zahedan University of Medical Science, Zahedan, Iran.|Department of Pharmacology, School of Medicine, Zahedan University of Medical Science, Zahedan, Iran.


| Kimia Tarah
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran


| Zahra Yavari
Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Azar Hosseini
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran


| Azita Aghaee
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran


| Hasan Rakhshandeh
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_13391.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2124421.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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