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Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۱، صفحات ۱۰۱-۱۱۳
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عنوان انگلیسی Evaluating bioactive constituents and toxicological effects of aqueous extract of fermented Pentaclethra macrophylla seeds in rats
چکیده انگلیسی مقاله Objective: This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of P. macrophylla. Material and Methods: The chemical constituents of fermented P. macrophylla were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were orally administered to male and female rats whereas 200, 400 and 800 mg/kg of the P. macrophylla extract were orally administered daily for 14 days in sub-acute toxicity investigation. Biochemical, haematological and lipid profiles were assessed following standard methods. Results: Bioactive compounds such as citronellol and oxirane, tetradecyl- (hexadecylene oxide) were identified in the extract. In acute toxicity test, no death or sign of toxicity was identified. For sub-acute study, ALT decreased significantly (p
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نویسندگان مقاله | Eziuche Amadike Ugbogu
Department of Biochemistry Abia State University, PMB 2000, Uturu, Abia State, Nigeria.


| Chukwumaobim Daniel Nwoku
Department of Biochemistry, Faculty of Pure and Applied Science, Federal University Wukari, PMB 1020, Wukari, Taraba State, Nigeria.


| Victor Chibueze Ude
Department of Medical Biochemistry, College of Medicine Enugu State University of Science and Technology, PMB 01660, Enugu-Nigeria.


| Okezie Emmanuel
Department of Biochemistry Abia State University, PMB 2000, Uturu, Abia State, Nigeria.
نشانی اینترنتی http://ajp.mums.ac.ir/article_13557.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2124424.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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