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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۲، صفحات ۲۵۱-۲۵۶
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عنوان انگلیسی Therapeutic effect of psoralen on muscle atrophy induced by tumor necrosis factor-α
چکیده انگلیسی مقاله Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (10 or 20 ng/ml) plus psoralen (80 μM) administration were investigated. Cell viability was assessed using Cell Counting Kit-8 (CCK-8) assay. Western blot analysis was used to detect protein expression of atrophic markers. Flowcytometry was used to observe the effect of psoralen on apoptosis. A quantitative real-time PCR (qRT-PCR) assay was performed to detect the mRNA level of miR-675-5P.Results: TNF-α (1, 10, 20 and 100 ng/ml) treatment inhibited C2C12 myoblast viability (P
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نویسندگان مقاله | Xin-Feng Lin
Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Qi-Long Jiang
Department of Spleen-Stomach, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Zhi-Long Peng
The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Yi-Le Ning
The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, 510405|Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Yuan-Yuan Luo
Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Fu Zhao
Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Xian Peng
The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, 510405


| Wei-Tao Chen
Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405|Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14290.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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