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Iranian Biomedical Journal، جلد ۲۴، شماره ۲، صفحات ۹۹-۱۰۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of Hair Follicle Stem Cells on Partial-Thickness Burn Wound Healing and Tensile Strength
چکیده انگلیسی مقاله Background: The recent improvements in wound healing have led to new strategies in regenerative medicine. Burn wound healing is an important issue in skin regeneration and has multiple indications for stem cell therapy. Hair follicle stem cells (HFSCs) are a highly promising source of stem cells for healing use, as these cells are accessible, active and pluripotent adult stem cells. Methods: HFSCs of the rat whisker were isolated, cultured, and labeled with DiI. Flow cytometry method was used to detect special markers of HFSCs. Deep partial-thickness burn wound was created, and labeled HFSCs were injected around the wound bed. Wound closure was recorded via digital photographs. The inflicted rats were sacrificed at 3, 7, or 14 days post burn and used for subsequent histological and tensiometry analysis. Results: Our results indicated that HFSCs were positive for Nestin and CD34 markers, but negative for Kr15. Morphological and histological photographs revealed that wound closure rate was accelerated in stem cell-treated group compared with other groups. In addition, faster re-epithelialization and collagen deposition were observed. The immunohistochemical analysis suggested that CD31 expression and vascular density enhanced in the stem cell-treated group. Further, tissue tensile strength increased in HFSCs-treated rats in comparison to the control group. Conclusion: The present study demonstrates that HFSC could accelerate burn wound healing as well as tensile strength in rats.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Azar Babakhani
Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Malihe Nobakht
Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Hamidreza Pazoki Torodi
Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mostafa Dahmardehei
Zahedan Medical University, Zahedan, Iran


| Paria Hashemi
Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Javad Mohajer Ansari
epartment of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Parisa Ramhormozi
Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Abazar Yari
Department of Anatomy, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran


| Fatemeh Heidari
Department of Anatomy, Faculty of Medicine, Qum University of Medical Sciences, Qum, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-789&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-2148667.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Tissue Engineering and Cell Biology
نوع مقاله منتشر شده مقاله کامل
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