این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
The Archives of Bone and Joint Surgery، جلد ۸، شماره ۱، صفحات ۵-۱۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Available Findings Fail to Provide Strong Evidence of the Role of Bone Morphogenic Protein-2 in Femoral Head Osteonecrosis
چکیده انگلیسی مقاله Background: Despite widespread research on non-traumatic femoral head osteonecrosis (FHON), there is noconsensus about preventative treatment options. Insufficient blood supply and increased intra-osseous pressure arethe initiating events in the majority of cases. BMPs are growth factors that belong to the transforming growth factor β(TGFβ) superfamily. Two specific formulations of BMPs have already been approved by the FDA: 1. BMP-2 (Infused,Medtronic) for the treatment of tibial open fractures and spinal fusion; 2. BMP-7 (OP-1, Stryker) in the setting of longbone non-:union:s. To our knowledge there is no published work reviewing the utility of BMP-2 in the setting of FHON.Methods: Online databases (EMBASE, Cochrane, MEDLINE and PubMed) for literature relating to the use of BMP-2in the treatment of FHON on 2nd June 2017.Results: Animal studies: A total of 169 animal subjects with induced FHON were treated with BMP-2 in all the includedin vivo studies.Improved histological parameters, areas of revascularization, areas of new bone formation and osteoid depositionwere seen in all studies. The number of osteoclasts decreased post operatively, in the ibandronate and BMP-2 group.Human studies: In combination, 96 human hips were treated in two studies utilizing BMP-2 and mean follow-up was atleast five years. Success rate of BMP-2 was above 80 % (based on Harris score and WOMAC score) in both studies.Both are level III studies.Conclusion: The present review of animal and clinical studies could not find well-designed prospective comparablestudies with large sample size and preliminary evidence is not sufficient to supports the utilization of BMP-2, and itsimpact on the midterm outcomes of FHON.Level of evidence: III
کلیدواژه‌های انگلیسی مقاله BMP-2, femoral head, Osteonecrosis
نویسندگان مقاله | Ali Parsa
Massachusetts General Hospital at Harvard Medical School, Boston, USA Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Science, Mashhad, Iran


| Hamed Vahedi
Rothman Orthopedic at Thomas Jefferson University, Philadelphia, PA, USA


| Karan Goswami
Royal London Hospital, London, UK


| Arash Aalirezaie
Rothman Orthopedic at Thomas Jefferson University, Philadelphia, PA, USA
نشانی اینترنتی http://abjs.mums.ac.ir/article_13969.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/328/article-328-2175984.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده CURRENT CONCEPTS REVIEW
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات