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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۶، صفحات ۵۰۴-۵۱۴
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چکیده فارسی مقاله
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عنوان انگلیسی Nano-SnCl4.SiO2, an efficient catalyst for synthesis of benzimidazole drivatives as antifungal and cytotoxic agents
چکیده انگلیسی مقاله The concept of green chemistry has made significant impact on many frontages including the use of green solvents or sustainable catalyst materials. Benzimidazole ring is an important nitrogen-containing heterocyclic, which exhibits a broad spectrum of bioactivities and are widely utilized by the medicinal chemists for drug discovery. A simple and efficient method was developed for the synthesis of some benzimidazole derivatives via reaction of o -phenylenediamine and substituted aldehydes in the presence of nano-SnCl 4 /SiO 2 as a mild catalyst. Ten 2-substituted benzimidazole compounds ( J 1 -J 10 ) were synthesized. All compounds were evaluated against different species of yeasts and filament fungi using broth micro dilution method as recommended by clinical and laboratory standard institute. Among these compounds, the active ones were chosen for their cytotoxic activities evaluation against MCF-7 and A549 cell lines using MTT method. Compound J 2 showed the best antifungal activity against all tested species. Compounds J 5 - J 7 had also desirable antifungal activities. Our cytotoxic results were also similar to the antifungal activities except for J 7 which had no cytotoxic activity.
کلیدواژه‌های انگلیسی مقاله Antifungal,Benzimidazole,Cytotoxic,MTT,Nano-SnCl4/SiO2
نویسندگان مقاله | Leila Zamani
1Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Zeinab Faghih
2Center of Basic Researches in Infectious Diseases, Department of Medical Mycology, and Parasitology School of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Kamiar Zomorodian
3Department of Chemistry, College of Science, Yazd University, Yazd, I.R. Iran.


| Bi Bi Fatemeh Mirjalili
1Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Asghar Jalilian
1Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Soghra Khabnadideh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1943
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-2233601.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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