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Acta Medica Iranica، جلد ۵۷، شماره ۷، صفحات ۴۰۵-۴۱۱
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عنوان انگلیسی Evaluation of the efficacy of probiotics in the treatment of infantile colic; a randomized, double blind; placebo controlled trial
چکیده انگلیسی مقاله Introduction: The infantile colic is one of the most common complaints in the infancy; however, limited therapeutic approaches are described in the literature. Recently probiotics have been suggested as a potential strategy in the treatment of infantile colic. We conducted this study with intend to investigate the efficacy of probiotics in relieving colic symptoms in Iranian infants. Methods: This double-blind clinical trial held among 70 infants aged 3 to 16 weeks with the presumed diagnosis of infantile colic according to Wessel criteria who were breastfed or formula fed. They were assigned at random to receive Pedilact®(Bifidobacterium infantis, Lactobacillus reuteri, and Lactobacillus rhamnosus) (N=33) or placebo (N=32). Demographic data were recorded in the questionnaires at the beginning of the study. The number of daily episodes of crying and fussiness, number of weekly crying days and duration of crying were separately analyzed on 7, 21 and 30th  days of investigation. Results: Baseline demographic data showed no statistically significant difference between intervention and placebo groups. Infants given Pedilact® showed a significant reduction in daily episodes of crying, duration of crying and the weekly number of crying days at the end of the treatment period compared with those receiving placebo. (P-value=0.000) On 21th day of the study, daily episodes of fuss and crying (P-value=0.032) and duration of crying reduced significantly in the intervention group in comparison to the placebo group. (P-value=0.000) Conclusions: Administration of Pedilact® drop significantly improved colic symptoms by reducing crying and fussing times in breastfed or formula fed in Iranian infants with colic.
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نویسندگان مقاله | Mojdeh Habibi Zoham
Assistant professor of Pediatric Intensive Care Unit, Department of Pediatric Intensive Care Unit, Bahrami children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Zahar Zafar
Assistant of pediatric Bahrami children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Armen Malekiantaghi
Assistant professor of pediatric gastroenterology, Department of Pediatric, Bahrami children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Reyhaneh Ettehadi
General practitioner, Department of Pediatric Intensive Care Unit, Bahrami children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Seyed Behnam Jazayeri
General practitioner, Department of Pediatric Intensive Care Unit, Bahrami children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Kambiz Eftekhari
Associate professor of pediatric gastroenterology, Pediatric gastroenterology and hepatology research center, Department of Pediatric, Bahrami children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7966
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