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Iranian Journal of Public Health، جلد ۴۹، شماره ۲، صفحات ۲۵۷-۲۶۶
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عنوان انگلیسی Expressions of CD23, IL-17 and MMP-9 in Patients with Colorectal Cancer
چکیده انگلیسی مقاله Background: We aimed to detect IL-17, MMP-9 and CD23 in serum of patients with colorectal cancer to provide some proper references for diagnosis and treatment of this disease. Methods: Overall, 287 patients with colorectal cancer were collected in the Digestive Surgery Department of Chinese PLA General Hospital, Beijing, China from January 2017 to November 2018 and were used as the study group, meanwhile, 200 people who took physical examination in the same period were used as the control group. They were retrospectively analyzed. The concentrations of IL-17, MMP-9 and CD23 in serum were detected by ELISA 10 d before and after treatment and 30 d after treatment. The relationship between IL-17, MMP-9 and CD23 concentration and clinicopathology was analyzed. Results: The concentrations of CD23, IL-17 and MMP-9 in peripheral blood of the patients in the study group were significantly higher than those in the control group (P< 0.001). IL-17, MMP-9 and CD23 were negatively correlated with treatment time and pathological features in the study group (P< 0.001). Conclusion: The concentrations of IL-17, MMP-9 and CD23 obviously increased in peripheral blood of patients with colorectal cancer, the three were negatively correlated with treatment time and were significantly correlated with TNM staging and differentiation degree of colorectal cancer. It is expected to estimate the illness.
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نویسندگان مقاله | Xueguang GUO
Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China


| Gang LIU
Department of Hepatobiliary & Enteric Surgery, Xiangya Hospital, Central South University, Changsha, China


| Xiaoping XIE
Department of Gastroenterology Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China


| Jing LI
Department of Oncology, Zhongshan Hospital Affiliated to Guangzhou University of Chinese Medicine, Zhongshan, China


| Zehui HOU
Department of Gastrointestinal and Hernia Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China


| Yanhong GU
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


| Lijiang YU
Department of Internal Medicine-Oncology, Jingjiang People&#x2019;s Hospital, Jingjiang, China
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/19573
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