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Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۲، صفحات ۱۴۳-۱۵۱
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عنوان انگلیسی Pomegranate peel extract inhibits internalization and replication of the influenza virus: An in vitro study
چکیده انگلیسی مقاله Objective: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it are limited. Our previous study showed anti-influenza virus activity of pomegranate peel extract (PPE). In this study, the mechanism through which PPE acts against influenza virus A/Puerto Rico/8/34 (H1N1; PR8) was investigated. Materials and Methods:Ethyl alcohol extract of pomegranate (Punica granatum L.) peel was prepared, and the action mechanism of PPE in inhibiting influenza replication was studied by time-of-drug-addition assay, virucidal activity, RNA replication, hemagglutination inhibition assay, viral mRNA expression, and western blot analysis. Results: PPE inhibited viral polymerase activity, viral RNA replication, and viral protein expression but could not affect hemagglutination inhibition and virucidal activity. According to time-of-drug-addition assay results, PPE inhibited the virus adsorption and early steps of influenza replication. Conclusion: This study demonstrated that the antiviral effect of PPE on influenza virus is most probably associated with inhibition of viral adsorption and viral RNA transcription.
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نویسندگان مقاله | Mohammad-Taghi Moradi
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.


| Ali Karimi
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.


| Mahmoud Rafieian-kopaei
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.


| Mohammad Rabiei-Faradonbeh
Department of Pathobiology, Infectious Disease and Public Health, School of Animal and Veterinary Sciences, University of Adelaide, Adelaide, Australia.


| Hassan Momtaz
Department of Microbiology, College of Veterinary Medicine, Shahrekord Branch, Islamic Azad University.
نشانی اینترنتی http://ajp.mums.ac.ir/article_13855.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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