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Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۲، صفحات ۱۶۱-۱۶۹
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عنوان انگلیسی Silymarin inhibits Toll-like receptor 8 gene expression and apoptosis in Ramos cancer cell line
چکیده انگلیسی مقاله Objective: Silymarin is a herbal extract containing flavonolignans, and it has inhibitory effects against the growth of different cancer cell lines by inducing apoptosis. Toll-like receptors are suggested as a novel and attractive target to treat cancer. The current study aimed at examining the mechanism of silymarin-induced apoptosis in Ramos cells and investigating its effects on TLR8 expression. Materials and Methods: The half maximal inhibitory concentration (IC50) of silymarin in Ramos cells was determined via MTT viability test while the type of cell death was tested by annexin V/propidium iodide (PI) double staining method. The activity of caspase-3 and expression of TLR8 were measured in a time-dependent manner (in IC50) by colorimetric assay and real-time polymerase chain reaction (RT-PCR), respectively. Results: The results of MTT showed that IC50 of silymarin in Ramos cells was 100 μg/ml after 48 hr treatment (p
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نویسندگان مقاله | Nasrin Ranjbar
Student Scientific Research Center, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.|Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.


| Ramin Saravani
Cellular and Molecular Research Center, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.|Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.


| Zohreh Faezizadeh
Department of Laboratory Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_13681.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2271554.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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