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International Journal of Radiation Research، جلد ۱۸، شماره ۲، صفحات ۱۹۱-۲۰۰
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عنوان انگلیسی Internal mammarial lymph node radiotherapy in obese patients with breast cancer, at what expense?
چکیده انگلیسی مقاله Background and Aim: The incidence of internal lymph node (IMN) involvement was 4- 65% in breast cancer patients. Despite studies indicating the positive effects of IMNRT on the oncological results, most of the clinicians avoided IMNRT because of the toxicity related to the increased dose of organs at risk (OAR). We aimed to compare the dosimetric results of RT plans with and without IMN containing planning target volumes (PTVs) using helical tomotherapy (HT) in obese patients. Materials and Methods: The PMRT data of 23 obese patients were evaluated retrospectively / dosimetrically. Two PTVs with and without IMN were defined and two separate plans were made with HT. Dose received by IMN and OAR were compared. Results: The untargeted IMN V40 were calculated between 0% to 99%. When the plans are evaluated in terms of critical organs, the inclusion of the IMN into the target volume, the most significant adverse effect was observed in heart doses in the left chest wall (CW) irradiation. The significant increases in cardiac V5 (%62.6 vs %48.6 p=0.007), V10 (%38.2 vs %23.2 p=0.011), V20 (%14.15 vs %9.06 p=0.045) and maximum heart dose (48.04 vs 43.2 p=0.043) were observed in the left-side CW irradiations that involving the IMN. In CW irradiation on the right side with IMN, only a significant increase in mean heart dose (5.44 vs 4.52 p=0.036) was observed. Lung V5 doses were increased by inclusion with IMN in both sides. There was no difference in the contralateral breast doses in both plans for both sides. Conclusions: If the IMN is not targeted, some of the patients are getting appropriate doses in obese patients.
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نویسندگان مقاله | I.P. Aral
Nevşehir Hospital, Department of Radiation Oncology, Nevsehir, Turkey


| S.A. Arslan
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| A.F. Yurekli
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| G.A. Inan
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| S. Tekin
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| H. Bozdemir
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| S. Sunel
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| H. Karabuga
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey


| S. Acıkgoz
Ankara Ataturk Education and Training Hospital, Department of Radiation Oncology, Ankara, Turkey
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-2055-3&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/42/article-42-2285873.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Medical Physics
نوع مقاله منتشر شده تحقیق بدیع
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