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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۴، صفحات ۴۹۴-۴۹۹
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عنوان انگلیسی Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats
چکیده انگلیسی مقاله Objective(s): This study aimed to evaluate the potential role of hydrogen in rats after cerebral ischemic/reperfusion (I/R) injury. Materials and Methods: The experimental samples were composed of sham group, model group of rats that received middle cerebral artery occlusion (MCAO) for 2 hr followed by reperfusion for 24 hr, and the hydrogen saline group treated by hydro‌gen-rich saline (1 ml/kg) after MCAO. Hydrogen sulfide (H2S), S100-βprotein (S100-β), and neuron-specific enolase (NSE) levels were measured; the levels of malondialdehyde (MDA), reactive oxygen species (ROS), and superoxide dismutase (SOD) were detected; the histologic structure and apoptotic cells of hippocampus were observed; the expressions of cystathionine β-synthase (CBS), nuclear factor erythroid 2-related factor 2 (Nrf2), and hemeoxygenase-1 (HO-1) were measured. Statistical analyses were performed using one-way analysis of variance (ANOVA) followed by Fisher’s least significant difference (LSD) test.Results: Our results showed that hydrogen up-regulated H2S levels via promoting the expression of CBS in the hippocampus, and its treatment alleviated oxidative stress via activating the expression of Nrf2 and HO-1, and then cell apoptosis reduced, furthermore, brain function improved by down-regulating the levels of S100-βand NSE. Conclusion: This study showed that hydrogen-rich saline ameliorates cell injury through up-regulating the expression of CBS in the hippocampus after cerebral ischemia reperfusion (I/R) in rats, this provides new experimental evidence for the treatment of stroke with hydrogen saline.
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نویسندگان مقاله | Haiming Cong
Department of Rehabilitation Medicine, Weihai Central Hospital, Wendeng 264400, China


| Qiu-ping Gao
Department of Emergency, Ji Nan Zhang Qiu District Hospital of Traditional Chinese Medicine, Zhang Qiu 250200, China


| Guo-qiang Song
Department of Neurosurgery, Ji Nan Zhang Qiu District Hospital of Traditional Chinese Medicine, Zhang Qiu 250200, China


| Yin-gxin Ye
Department of Neurology, Ji Nan Zhang Qiu District Hospital of TraditionalChinese Medicine, Zhang Qiu 250200, China


| Xiao-li Li
Department of Critical Care Medicine, Yu Huang Ding Hospital, Qingdao University, Yantai, P. R. China


| Lian-shuang Zhang
Department of Histology and Embryology, Binzhou Medical University, Yantai, P. R. China


| Xi-feng Wang
Department of Critical Care Medicine, Yu Huang Ding Hospital, Qingdao University, Yantai, P. R. China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14868.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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