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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۴، صفحات ۵۲۷-۵۳۳
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عنوان انگلیسی The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats
چکیده انگلیسی مقاله Objective(s): Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice. The aim of this survey was to appraise the effect of lycopene and the ESM nerve guidance channel on sciatic nerve regeneration.Materials and Methods: In this study, 32 male rats were randomized into four groups: sham surgery, autograft, ESM+ dimethyl sulfoxide (DMSO), and ESM+lycopene. One centimeter of sciatic nerve was removed, and the gap was grafted by ESM channel or autograft. The sciatic function index (SFI) was evaluated at days 7, 21, 30, 49, 60 and 90 after surgery. Nerve regeneration and gastroknemius muscle fibers were evaluated at days 30 and 90 after surgery by withdrawal reflex latency (WRL), histology and immunohistology assessments.Results: At 49, 60 and 90 days after surgery, the mean SFI in ESM+lycopene group was significantly greater than ESM+DMSO group (P
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نویسندگان مقاله | Gholam Hossein Farjah
Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Samad Mohammadzadeh
Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Masoumeh Zirak Javanmard
Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14869.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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