این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۵، شماره ۲، صفحات ۱۱۷-۱۲۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Changes in Cytokeratin 18 during Neoadjuvant Chemotherapy of Breast Cancer: A Prospective Study
چکیده انگلیسی مقاله Background & Objective: Prediction of response to neoadjuvant treatment is an important part of treatment of patients with breast cancer. This study aimed to assess changes in serum levels of Cytokeratin 18 during neoadjuvant chemotherapy in patients with locally advanced breast cancer and its association with neoadjuvant treatments. Methods: This research was performed on newly diagnosed breast cancer patients referred to Omid Radiotherapy Center and radiotherapy and oncology departments of Emam Reza and Ghaem hospitals, in Mashhad, Iran. Serum levels of M30 and M65 fragments of Cytokeratin 18 were measured before and 24 hours after the first course of neoadjuvant chemotherapy. Changes in serum levels of Cytokeratin 18 and its fragments and their correlation with pathologic response were analyzed. Results: Pre- and post-chemotherapy levels of M30 were respectively 223.9±18.94 and 250.7±23.92 U/L (P=0.24). For M65, these levels were respectively 301.5±313.9 and 330.2±352.2 U/L (P=0.1). Changes in M30 level during chemotherapy in patients with and without pathologic complete response were -20±92.69 and 43.1±106.5, respectively (P=0.1). For M65, these changes were respectively -247±55 and 76±240 (P=0.1). Baseline levels of M30 and M65 had no relation with menopausal status, tumor grade, hormone receptor status, Ki67 expression, molecular subtype, and stage. Conclusion: Our findings showed statistically insignificant changes in the level of Caspase-cleaved- (M30) and uncleaved- (M65) cytokeratin 18 fragments (apoptotic and necrotic indicators, respectively) during neoadjuvant chemotherapy in patients with breast cancer. There was no notable relationship between tumor-related factors and either baseline levels or serum changes of CK18 fragments. Also, there was no correlation between M30/M65 level and pathologic response to neoadjuvant chemotherapy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله Danial Fazilat-Panah |
Cancer Research Center, Babol University of Medical Sciences, Babol, Iran

Somaye Vakili Ahrari Roudi |
Department of Pathology, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

Alireza Keramati |
Department of Radio-Oncology, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

Azar Fanipakdel |
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad hadi Sadeghian |
Department of Pathology, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Homaei Shandiz |
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Soudabeh ShahidSales |
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Alireza Javadinia |
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran

نشانی اینترنتی http://ijp.iranpath.org/article_38306_35ac16669b04b86a385364a16a3aa7ab.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-2314770.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات