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Iranian Journal of Pathology، جلد ۱۵، شماره ۲، صفحات ۱۳۴-۱۴۳
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عنوان انگلیسی Desmoplastic Fibroma of the Jaws: A Case Series and Review of Literature
چکیده انگلیسی مقاله Desmoplastic fibroma (DF) is a benign, locally aggressive neoplasm that rarely occurs in the facial skeleton. It usually presents during the first three decades of life. Due to its aggressiveness and high recurrence rate, early diagnosis is imperative, and complete surgical removal of the lesion is the treatment of choice. Herein, we present three cases of DF namely a 2 year-old girl with a mandibular DF, a 9 year-old boy with a maxillary lesion and a 1.5-year old boy with a mandibular DF. Complete clinicopathological information, treatment plan and long-term follow-up of patients are discussed. Histopathologic features of 3 cases revealed non-capsulated spindle cell tumor with fascicular or swirling patterns in incisional biopsy. Immunohistochemical staining was performed to make a definitive diagnosis. Strongly positive nuclear immunoreactivity for β-catenin confirmed the diagnosis of desmoplastic fibroma in 3 cases. Segmental mandibulectomy, partial maxillectomy and hemimandibulectomy were done for the cases. There was no recurrence in our reported cases after 8 and 11 months and 3 years follow up, respectively. It is noteworthy that despite the aggressive nature of DF, young patients often respond well to wide resection treatment.
کلیدواژه‌های انگلیسی مقاله Benign, Desmoplastic, Fibroma, Jaw
نویسندگان مقاله Abbas Karimi |
Department of Oral and Maxillofacial Surgery, Dentistry School, Tehran University of Medical Sciences, Tehran, Iran

Samira Derakhshan |
Department of Oral and Maxillofacial Pathology, Dentistry School, Tehran University of Medical Sciences, International Campus, Tehran, Iran

Monir Moradzadeh Khiavi |
Department of Oral and Maxillofacial Pathology, Dentistry School, Tehran University of Medical Sciences, Tehran, Iran

Farzaneh Mosavat |
Department of Oral and Maxillofacial Radiology, Dentistry School, Tehran University of Medical Sciences, Tehran, Iran

Faeze Mirjalili |
Department of Oral and Maxillofacial Radiology, Dentistry School, Kashan University of Medical Sciences, Kashan, Iran

نشانی اینترنتی http://ijp.iranpath.org/article_38308_2bfefb63eb6fc71fc1110334ae437757.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-2314772.pdf
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